Nat Rev Mol Cell Biol. 2002 Sep;3(9):639-50.

Seven-transmembrane receptors.

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The Howard Hughes Medical Institute and the Department of Medicine, Box 3821, Duke University Medical Center, Durham, North Carolina 27710, USA.

Abstract

Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.

PMID:: 12209124; [PubMed - indexed for MEDLINE]

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