Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Neurosci. 2002 Sep;3(9):748-55.

Beyond the role of glutamate as a neurotransmitter.

Author information

  • 1Department of Cell Biology and Anatomy, New York Medical College, Valhalla, New York 10595, USA.


Glutamate is the principal excitatory neurotransmitter of the central nervous system, but many studies have expanded its functional repertoire by showing that glutamate receptors are present in a variety of non-excitable cells. How does glutamate receptor activation modulate their activity? Do non-excitable cells release glutamate, and, if so, how? These questions remain enigmatic. Here, we review the current knowledge on glutamatergic signalling in non-neuronal cells, with a special emphasis on astrocytes.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk