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J Allergy Clin Immunol. 2002 Sep;110(3):341-8.

Anaphylaxis: a review of causes and mechanisms.

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  • 1Division of Allergy and Immunology, Department of Medicine, The University of Mississippi Medical Center, Jackson, USA.


Anaphylaxis is a life-threatening syndrome resulting from the sudden release of mast cell- and basophil-derived mediators into the circulation. Foods and medications cause most anaphylaxis for which a cause can be identified, but virtually any agent capable of directly or indirectly activating mast cells or basophils can cause this syndrome. This review discusses the pathophysiologic mechanisms of anaphylaxis, its causes, and its treatment.

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