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Eur J Immunol. 2002 Sep;32(9):2418-26.

HLA-G inhibits the functions of murine dendritic cells via the PIR-B immune inhibitory receptor.

Author information

  • 1Institute of Molecular Medicine and Genetics, Department of Medicine, Medical College of Georgia, Augusta 30912, USA.

Abstract

Human histocompatibility leukocyte antigen (HLA)-G is an MHC class Ib molecule that has been proposed to regulate immune responses during pregnancy. One of the possible mechanisms of that modulation is based on its interaction with immunoglobulin-like transcript (ILT) receptors. In this study, we show that HLA-G modifies the function of murine dendritic cells via interactions with the paired immunoglobulin-like inhibitory receptor, a homologue of the human inhibitory receptor ILT4. Triggering of the immune inhibitory receptors resulted in prolongation of allogeneic graft survival. This demonstration forms the basis for exploring and exploiting HLA-G molecules and immune inhibitory receptors in the development of a new therapeutic strategy to improve allogeneic graft survival.

PMID:
12207326
[PubMed - indexed for MEDLINE]
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