Display Settings:

Format

Send to:

Choose Destination
Ann Neurol. 2002 Sep;52(3):359-64.

Exclusion mapping of the genetic predisposition for cervical artery dissections by linkage analysis.

Author information

  • 1Department of Neurology, University of Heidelberg, Heidelberg, Germany. grond-ginsbach@med.uni-heidelberg.de

Abstract

Skin biopsies from a patient with a dissection of the left internal carotid artery and from four of his children were analyzed by electron microscopy. The index patient and three children showed mild but regular electron microscopic connective tissue aberrations. They were considered as carriers of an unknown autosomal dominant mutation. Thirty-four candidate genes involved in the biosynthesis of the extracellular matrix were excluded by genetic linkage analysis as possible sites of a disease-causing mutation in this family (logarithm of odds [LOD]-score less than -2.0).

PMID:
12205651
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk