Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Neurosci Biobehav Rev. 2002 Jun;26(4):485-98.

The temporal organization of ingestive behaviour and its interaction with regulation of energy balance.

Author information

  • 1Division of Neuroendocrinology, Department of Animal Physiology, School of Cognitive and Behavioural Neurosciences, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands. j.h.strubbe@biol.rug.ac.nl

Abstract

Body weight of man and animals is under homeostatic control mediated by the adjustment of food intake. It is discussed in this review that besides signals reporting energy deficits, optimized programs of body clocks take part in feeding behaviour as well. Circadian light- and food-entrainable clocks determine anticipatory adaptive behavioural and physiological mechanisms, promoting or inhibiting food intake. In fact these clocks form the constraints within which the homeostatic regulation of feeding behaviour is operating. Therefore, a strong interaction between circadian and homeostatic regulation must occur. In this homeostatic control, a wide variety of regulatory negative feedback mechanisms, or satiety signals, play a dominant role. In this respect several gut hormones and body temperature function as 'short-term' satiety factors and determine meal sizes and intermeal intervals. Leptin, secreted by fat cells in proportion to the size of adipose tissue mass, is probably an important determinant of the 'long-term' regulation of feeding behaviour by setting the motivational background level for feeding behaviour. Thus, initiation or termination of meals at any particular point in time, depends on the resultant of all satiety signals and on constraints imposed by circadian light- and food-entrainable oscillators.

PMID:
12204194
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk