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Cell. 2002 Aug 23;110(4):399-402.

Brain repair by endogenous progenitors.

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  • 1Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA.


Stem cells within the adult brain can be stimulated by injury and growth factor treatment to replace damaged neurons, even neurons that are not normally generated in adults. Coupled with recent insights into the mechanism by which Nogo inhibits axonal regeneration, this discovery may inspire new treatments for central nervous system injuries and neurodegenerative diseases.

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