Severe symptomatic osteoporosis in patients on androgen deprivation therapy for prostatic carcinoma

Scand J Urol Nephrol. 2002;36(4):314-6. doi: 10.1080/003655902320248317.

Abstract

We report 3 patients referred to the bone clinic after spinal fractures. Dual energy X-ray absorptiometry showed severe osteoporosis. Each patient was found to have a history of prostatic carcinoma and long-term treatment with goserelin. We suggest that all patients who have received androgen deprivation therapy for more than 1 year should be evaluated by bone densitometry.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents, Hormonal / administration & dosage
  • Antineoplastic Agents, Hormonal / adverse effects*
  • Carcinoma / drug therapy*
  • Carcinoma / pathology
  • Densitometry
  • Femoral Fractures / diagnosis
  • Femoral Fractures / etiology
  • Follow-Up Studies
  • Fractures, Spontaneous / diagnosis
  • Fractures, Spontaneous / etiology*
  • Goserelin / administration & dosage
  • Goserelin / adverse effects*
  • Humans
  • Male
  • Osteoporosis / chemically induced*
  • Osteoporosis / complications
  • Osteoporosis / diagnosis
  • Prostatic Neoplasms / drug therapy*
  • Prostatic Neoplasms / pathology
  • Risk Assessment
  • Severity of Illness Index
  • Spinal Fractures / diagnosis
  • Spinal Fractures / etiology
  • Thoracic Vertebrae / injuries

Substances

  • Antineoplastic Agents, Hormonal
  • Goserelin