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Curr Opin Genet Dev. 2002 Oct;12(5):565-71.

Why size matters: altering cell size.

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  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA.


Several genes involved in growth control have lately been demonstrated to exhibit more potent effects on cell size than on cell proliferation. Many of these genes direct protein and ribosomal synthesis, highlighting the interdependence between cell size and macromolecular content. The failure to maintain normal cell size when these genes are deregulated suggests that, in certain contexts, cell growth and division are not coupled or coordinated. Several physiological repercussions of altering cell size have been identified.

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