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Curr Opin Genet Dev. 2002 Oct;12(5):524-33.

CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

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  • 1Department of Genetics University of Cambridge, Downing Street, CB2 3EH, Cambridge, UK.


During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However, there is increasing evidence that Notch can signal in CSL-independent modes.

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