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Curr Opin Genet Dev. 2002 Oct;12(5):512-8.

Intramembrane proteolysis controls diverse signalling pathways throughout evolution.

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  • 1MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK.


Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.

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