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Pharmaceutical availability of clobetasol-17-propionate from cream and ointment.
Department of Clinical Pharmacy, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
Kinetics of drug release from both compared preparations available as a cream and an ointment, was in vitro studied. A reversed-phase HPLC method was developed for the determination of clobetasol-17-propionate in lipophylic bases using clobetasol-17-butyrate as an internal standard. Analyses were performed using a C18 reversed-phase column with a mobile phase of methanol-water and ultraviolet detection at lambda=254 nm. The calibration curve was constructed for the concentration range 0.5-40.0 microg/ml. The method is simple, accurate and precise.
PMID: 12197615 [PubMed - indexed for MEDLINE]
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Patient Drug Information
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Betamethasone Topical (Alphatrex® , Betatrex® , Beta-Val® , ...)
Betamethasone is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions.
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Clobetasol (Clobevate® , Cormax® , Cormax® Scalp Application, ...)
Clobetasol is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin and scalp conditions.