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Neurology. 2002 Aug 27;59(4):633-6.

Temporal lobectomy for epilepsy: recovery of the contralateral hippocampus measured by (1)H MRS.

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  • 1MR Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco 94121, USA.

Abstract

(1)H MRS imaging was obtained from 10 patients with mesial temporal lobe epilepsy before and after surgery. After surgery, metabolic recovery in the contralateral hippocampus was detected. Preoperatively, reduced N-acetylaspartate (p < 0.04) increased after surgery nonsignificantly to equal control values. Cholines increased after surgery (p < 0.02) and creatine-phosphocreatine showed a trend to higher values. The results suggest that the contralateral hippocampus is affected by repeated seizure activity in the ipsilateral hippocampus, rather than presence of bilateral mesial temporal sclerosis.

PMID:
12196667
[PubMed - indexed for MEDLINE]
PMCID:
PMC2753242
Free PMC Article
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