Abstract
Four new naphthylisoquinoline alkaloids, ancistrocongolines A-D (4-7) were isolated from Ancistrocladus congolensis, along with the known compound korupensamine A (8). Structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods. Their biological activities against the pathogens of malaria, Leishmaniasis, Chagas disease, and African sleeping sickness were evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antimalarials / chemistry
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Antimalarials / isolation & purification
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Antimalarials / pharmacology
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / isolation & purification*
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Antiprotozoal Agents / pharmacology
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Cells, Cultured / drug effects
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Chromatography, High Pressure Liquid
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Congo
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Inhibitory Concentration 50
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Isoquinolines / chemistry
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Isoquinolines / isolation & purification*
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Isoquinolines / pharmacology
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Leishmania / drug effects
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Molecular Conformation
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Molecular Structure
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Muscles / cytology
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Muscles / drug effects
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Naphthalenes / chemistry
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Naphthalenes / isolation & purification*
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Naphthalenes / pharmacology
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Plant Bark / chemistry
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Plant Roots / chemistry
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Plant Stems / chemistry
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Plants, Medicinal / chemistry*
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Plasmodium falciparum / drug effects
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Rats
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Stereoisomerism
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Trypanocidal Agents / chemistry
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Trypanocidal Agents / isolation & purification
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Trypanocidal Agents / pharmacology
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Trypanosoma brucei rhodesiense / drug effects
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Trypanosoma cruzi / drug effects
Substances
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Alkaloids
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Antimalarials
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Antiprotozoal Agents
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Isoquinolines
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Naphthalenes
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Trypanocidal Agents
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korupensamine A