Funct Integr Genomics. 2002 Sep;2(4-5):154-70. Epub 2002 Jun 5.

Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae.

De Hertogh B, Carvajal E, Talla E, Dujon B, Baret P, Goffeau A.

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Unité de Génétique, Faculté d'Agronomie, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.

Abstract

On the basis of functional and phylogenetic criteria, we have identified a total of 229 subfamilies and 111 singletons predicted to carry out transport or other membrane functions in Saccharomyces cerevisiae. We have extended the Transporter Classification (TC) and created a Membrane Classification (MC) for non-transporter membrane proteins. Using the preliminary phylogenetic digits X, Y, Z (for new families, subfamilies, and clusters, respectively), we allocated a five-digit number to 850 proteins predicted to contain more than two transmembrane domains. Compared with a previous TC of the yeast genome, we classified an additional set of 538 membrane proteins (transporters and non-transporters) and identified 111 novel phylogenetic subfamilies.

PMID:: 12192589; [PubMed - indexed for MEDLINE]

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