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1: Curr Opin Rheumatol. 2002 Sep;14(5):553-61. Links

Juvenile scleroderma.

Athreya BH.

Department of Pediatrics, Thomas Jefferson University/Jefferson Medical College Philadelphia, Pennsylvania, USA. bathreya@nemours.org

Scleroderma is a relatively rare disorder in children. Among its subsets, localized scleroderma is more common in children than the systemic variety. No exciting new finding was reported in 2001 specifically applicable to childhood scleroderma. However, many new advances in our understanding of the growth factors, cytokines, and chemokines were reported. These studies should help us to understand the pathogenesis of early lesions of scleroderma, vascular changes, and fibrosis and perhaps lead us toward more rational therapy.

PMID: 12192254 [PubMed - indexed for MEDLINE]

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