Send to

Choose Destination
See comment in PubMed Commons below
Trends Cell Biol. 2002 Aug;12(8):355-7.

The barrier function of skin: how to keep a tight lid on water loss.

Author information

  • 1Dept of Cell and Molecular Biology, The Feinberg School of Medicine at Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611, USA.


Without an epidermis, we would be in a sorry state. The epidermal layer not only protects us from environmental pathogens but also acts as a 'barrier' to water loss. The identification of the molecular nature of the barrier has occupied the efforts of skin researchers over many years, with the consensus in the field being that a protein-lipid layer, located in the upper layers of the epidermis, is necessary for establishment and maintenance of a water barrier. Now, evidence has been presented that components of intercellular junctions, termed tight junctions, also play an essential role in development of barrier function in the skin. Remarkably, the data support a hypothesis that was presented more than 30 years ago.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk