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Funct Integr Genomics. 2002 Aug;2(3):81-91. Epub 2002 Mar 9.

Functional genomics in the mouse.

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  • Pathology and Molecular, Cellular, Developmental Biology, Yale University, P.O. Box 208023, New Haven, CT 06520-8023, USA. archibald.perkins@yale.edu


The mouse is the premier genetic model organism for the study of human disease and development. With the recent advances in sequencing of the human and mouse genomes, there is strong interest now in large-scale approaches to decipher the function of mouse genes using various mutagenesis technologies. This review discusses what tools are currently available for manipulating and mutagenizing the mouse genome, such as ethylnitrosourea and gene trap mutagenesis, engineered inversions and deletions using the cre-lox system, and proviral insertional mutagenesis in somatic cells, and how these are being used to uncover gene function.

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