Principles of microbial alchemy: insights from the...[Genome Biol. 2002]

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1: Genome Biol. 2002 Jun 26;3(7):REVIEWS1020. Epub 2002 Jun 26. Links

Principles of microbial alchemy: insights from the Streptomyces coelicolor genome sequence.

Thompson CJ, Fink D, Nguyen LD.

Biozentrum, University of Basel, Division of Molecular Microbiology, 70 Klingelbergstrasse, 4056 Basel, Switzerland. Charles-J.Thompson@unibas.ch

The world's most creative producers of natural pharmaceutical compounds are soil-dwelling bacteria classified as Streptomyces. The availability of the recently completed Streptomyces coelicolor genome sequence provides a link between the folklore of antibiotics and other bioactive compounds to underlying biochemical, molecular genetic and evolutionary principles.

PMID: 12184813 [PubMed - indexed for MEDLINE]

PMCID: PMC139385

ReviewImpact of the first Streptomyces genome sequence on the discovery and production of bioactive substances.
Appl Microbiol Biotechnol. 2002 Dec; 60(4):377-80. Epub 2002 Oct 24.

[Appl Microbiol Biotechnol. 2002]
ReviewPlasticity of the streptomyces genome-evolution and engineering of new antibiotics.
Curr Med Chem. 2005; 12(14):1697-704.

[Curr Med Chem. 2005]
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).
Nature. 2002 May 9; 417(6885):141-7.

[Nature. 2002]
Identification of Streptomyces coelicolor genes involved in regulation of antibiotic synthesis.
Gene. 1992 Jun 15; 115(1-2):55-60.

[Gene. 1992]
Systematic insertional mutagenesis of a streptomycete genome: a link between osmoadaptation and antibiotic production.
Genome Res. 2004 May; 14(5):893-900. Epub 2004 Apr 12.

[Genome Res. 2004]
» See reviews... | » See all...

Cited by 2 PubMed Central articles

Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor.
Lu YW, San Roman AK, Gehring AM. J Bacteriol. 2008 Oct; 190(20):6903-8. Epub 2008 Aug 8.

[J Bacteriol. 2008]
Regulation of LiaRS-dependent gene expression in bacillus subtilis: identification of inhibitor proteins, regulator binding sites, and target genes of a conserved cell envelope stress-sensing two-component system.
Jordan S, Junker A, Helmann JD, Mascher T. J Bacteriol. 2006 Jul; 188(14):5153-66.

[J Bacteriol. 2006]

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