Format

Send to:

Choose Destination
See comment in PubMed Commons below
Peptides. 2002 Aug;23(8):1507-15.

G protein-dependent activation of mast cell by peptides and basic secretagogues.

Author information

  • 1Laboratoire de Neuroimmunopharmacologie, Facult√© de Pharmacie, INSERM U425, Universit√© Louis Pasteur-Strasbourg I, bp 24, 67401 Illkirch Cedex, France.

Abstract

Signaling pathways leading to exocytosis and arachidonate release from serosal mast cells by basic secretagogues, including cationic peptides, arise from the involvement of betagamma subunits from G(i2) and G(i3) GTP-binding proteins. The original concept that basic secretagogues directly interact with G proteins implicated the entry of secretagogues into mast cells. This has been demonstrated only for the neuropeptide substance P. Basic secretagogues might share a common mechanism of penetration with the newly described cell-penetrating peptides. The involvement of some membrane transporter or non-selective membrane receptor to basic secretagogues cannot be excluded.

Copyright 2002 Elsevier Science Inc.

PMID:
12182955
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk