Total synthesis of proposed amphidinolide A via a highly selective ring-closing metathesis

Robert E Maleczka Jr; Lamont R Terrell; Feng Geng; Joseph S Ward 3rd

doi:10.1021/ol0262284

Total synthesis of proposed amphidinolide A via a highly selective ring-closing metathesis

Org Lett. 2002 Aug 22;4(17):2841-4. doi: 10.1021/ol0262284.

Authors

Robert E Maleczka Jr¹, Lamont R Terrell, Feng Geng, Joseph S Ward 3rd

Affiliation

¹ Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA. maleczka@cem.msu.edu

PMID: 12182569
DOI: 10.1021/ol0262284

Abstract

[structure: see text] A highly convergent synthesis of the proposed structure of amphidinolide A is reported. Instructive applications of several organometallic processes are illustrated, including a highly selective ring-closing metathesis reaction.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antineoplastic Agents / chemical synthesis
Cyclization
Ephedrine / chemistry
Lactones / chemical synthesis*
Macrolides / chemical synthesis*
Marine Toxins / chemical synthesis*

Substances

Antineoplastic Agents
Lactones
Macrolides
Marine Toxins
amphidinolide A
Ephedrine