Am J Physiol Gastrointest Liver Physiol. 2002 Sep;283(3):G496-502.

The epithelial cell cytoskeleton and intracellular trafficking. III. How is villin involved in the actin cytoskeleton dynamics in intestinal cells?

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Laboratoire de morphogénèse et signalisation cellulaires, Institut Curie UMR 144, 75248 Paris cedex 05, France.

Abstract

Villin plays a key role in the maintenance of the brush border organization by bundling F-actin into a network of parallel filaments. Our previous in vivo data on villin knockout mice showed that, although this protein is not necessary for the bundling of F-actin, it is important for the reorganization of the actin cytoskeleton elicited by stress conditions. We further investigated villin property to initiate actin remodeling in cellular processes such as hepatocyte growth factor-induced motility, morphogenesis, and bacterial infection. Our data suggest that villin is involved in actin remodeling necessary for many cellular processes requiring the actin cytoskeleton plasticity.

PMID:: 12181160; [PubMed - indexed for MEDLINE]

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Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells. [Mol Biol Cell. 2003]
Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells.
Athman R, Louvard D, Robine S. Mol Biol Cell. 2003 Nov; 14(11):4641-53. Epub 2003 Aug 22.
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Suppression of villin expression by antisense RNA impairs brush border assembly in polarized epithelial intestinal cells. [EMBO J. 1995]
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Friederich E, Pringault E, Arpin M, Louvard D. Bioessays. 1990 Sep; 12(9):403-8.
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Review Regulation of cell structure and function by actin-binding proteins: villin's perspective.
Khurana S, George SP. FEBS Lett. 2008 Jun 18; 582(14):2128-39. Epub 2008 Feb 26.

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