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Neurology. 2002 Aug 13;59(3):445-8.

Dopamine transmission in DYT1 dystonia: a biochemical and autoradiographical study.

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  • 1Center for Aging, Genetics, and Neurodegeneration, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA. augood@helix.mgh.harvard.edu

Abstract

Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D(1) receptor and D(2) receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.

PMID:
12177384
[PubMed - indexed for MEDLINE]
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