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Genome Res. 2002 Aug;12(8):1185-9.

Minimal introns are not "junk".

Author information

  • 1University of Washington Genome Center, Department of Medicine, Seattle, Washington 98195, USA. junyu@u.washington.edu

Abstract

Intron-size distributions for most multicellular (and some unicellular) eukaryotes have a sharp peak at their "minimal intron" size. Across the human population, these minimal introns exhibit an abundance of insertion-deletion polymorphisms, the effect of which is to maintain their optimal size. We argue that minimal introns affect function by enhancing the rate at which mRNA is exported from the cell nucleus.

PMID:
12176926
[PubMed - indexed for MEDLINE]
PMCID:
PMC186636
Free PMC Article

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