Curr Biol. 2002 Jul 23;12(14):R496-8.

Gem GTPase: between a ROCK and a hard place.

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Abramson Family Cancer Research Institute, BRB II/III, 421 Curie Blvd., University of Pennsylvania, Philadelphia 19104, USA. molson@mail.med.upenn.edu

Abstract

Gem GTPase is a member of a protein family that includes Rad, Rem and Rem2. Although until recently precious little was known about the function of Gem, recent studies have revealed that Gem may influence cell morphology by antagonising the actions of the Rho GTPase effector protein ROCK I.

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