Cell. 2002 Aug 9;110(3):281-4.

Dynamic remodeling of transcription complexes by molecular chaperones.

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Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA. r-morimoto@northwestern.edu

Abstract

The assembly and disassembly of macromolecular transcription complexes represents a key step in the regulation of gene expression. For inducible responses to hormones and stress, different combinations of molecular chaperones govern the activities of intracellular hormone receptors and heat shock transcription factor. Through their capacity to remodel the conformation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible transcriptional response.

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Dynamic remodeling of transcription complexes by molecular chaperones.

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