Cell. 2002 Aug 9;110(3):277-80.

LINE drive. retrotransposition and genome instability.

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Department of Genetics, School of Medicine, 475 Clinical Research Building, 415 Curie Boulevard, University of Pennsylvania, Philadelphia 19105, USA. kazazian@mail.med.upenn.edu

Abstract

The LINE-1 (L1) retrotransposon, the most important human mobile element, shapes the genome in many ways. Now two groups provide evidence that L1 retrotransposition is associated with large genomic deletions and inversions in transformed cells. If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution.

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Genomic deletions created upon LINE-1 retrotransposition. [Cell. 2002]
Genomic deletions created upon LINE-1 retrotransposition.Gilbert N, Lutz-Prigge S, Moran JV. Cell. 2002 Aug 9; 110(3):315-25.
Human l1 retrotransposition is associated with genetic instability in vivo. [Cell. 2002]
Human l1 retrotransposition is associated with genetic instability in vivo.Symer DE, Connelly C, Szak ST, Caputo EM, Cost GJ, Parmigiani G, Boeke JD. Cell. 2002 Aug 9; 110(3):327-38.

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Genomic deletions created upon LINE-1 retrotransposition. [Cell. 2002]
Genomic deletions created upon LINE-1 retrotransposition.
Gilbert N, Lutz-Prigge S, Moran JV. Cell. 2002 Aug 9; 110(3):315-25.
Human l1 retrotransposition is associated with genetic instability in vivo. [Cell. 2002]
Human l1 retrotransposition is associated with genetic instability in vivo.
Symer DE, Connelly C, Szak ST, Caputo EM, Cost GJ, Parmigiani G, Boeke JD. Cell. 2002 Aug 9; 110(3):327-38.
L1 recombination-associated deletions generate human genomic variation. [Proc Natl Acad Sci U S A. 2008]
L1 recombination-associated deletions generate human genomic variation.
Han K, Lee J, Meyer TJ, Remedios P, Goodwin L, Batzer MA. Proc Natl Acad Sci U S A. 2008 Dec 9; 105(49):19366-71. Epub 2008 Nov 26.
Review [Genomic instability associated with human LINE-1 rétrotransposition]. [J Soc Biol. 2004]
Review [Genomic instability associated with human LINE-1 rétrotransposition].
Gilbert N, Doucet AJ, Bucheton A. J Soc Biol. 2004; 198(4):419-24.
Review A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease. [Hum Genet. 2005]
Review A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease.
Chen JM, Stenson PD, Cooper DN, Férec C. Hum Genet. 2005 Sep; 117(5):411-27. Epub 2005 Jun 28.

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