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Trends Genet. 2002 Sep;18(9):434-7.

Antisense RNA in imprinting: spreading silence through Air.

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  • 1Unité de Génétique Moléculaire Murine, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France. rougell@pasteur.fr


In some animals, including mammals, a number of genes are expressed differently according to whether they have been inherited from the mother or from the father, through a process known as genomic imprinting. Noncoding RNAs have increasingly been found associated with imprinted genes, but their role, if any, has remained enigmatic. A recent study provides the first evidence that, at least in one case, a noncoding RNA has a direct role in regulating imprinted gene expression in cis.

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