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J Appl Microbiol. 2002;93(3):398-405.

Garlic (Allium sativum) as an anti-Candida agent: a comparison of the efficacy of fresh garlic and freeze-dried extracts.

Author information

  • 1Microbiology (BIOSI 1), Cardiff University, Cardiff, Wales, UK. Lemarkm@cf.ac.uk

Abstract

AIMS:

To determine the effects of fresh and freeze-dried extracts of Allium sativum on the physiology and morphology of Candida albicans.

METHODS AND RESULTS:

Inhibition of growth in glucose-yeast extract-peptone was measured using a multiwell plate reader. Scanning and transmission electron microscopy investigations indicated loss of structural integrity. Gas chromatography-mass spectrometry of extracts was employed to separate and quantify putative inhibitory sulphur-containing components.

CONCLUSIONS:

Fresh garlic extract has a greater efficacy than garlic powder extract as indicated both by its effects on morphology and inhibition of growth.

SIGNIFICANCE AND IMPACT OF THE STUDY:

The ubiquitous opportunistic pathogen C. albicans is sensitive to garlic; resistance to the broad spectrum of active principles present is unlikely so that its anticandidal effects may provide an important alternative route to chemotherapy.

PMID:
12174037
[PubMed - indexed for MEDLINE]
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