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Plant Cell. 2002 Aug;14(8):1787-99.

FRD3, a member of the multidrug and toxin efflux family, controls iron deficiency responses in Arabidopsis.

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  • 1Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA. rogersee@missouri.edu

Abstract

We present the cloning and characterization of an Arabidopsis gene, FRD3, involved in iron homeostasis. Plants carrying any of the three alleles of frd3 constitutively express three strategy I iron deficiency responses and misexpress a number of iron deficiency-regulated genes. Mutant plants also accumulate approximately twofold excess iron, fourfold excess manganese, and twofold excess zinc in their shoots. frd3-3 was first identified as man1. The FRD3 gene is expressed at detectable levels in roots but not in shoots and is predicted to encode a membrane protein belonging to the multidrug and toxin efflux family. Other members of this family have been implicated in a variety of processes and are likely to transport small organic molecules. The phenotypes of frd3 mutant plants, which are consistent with a defect in either iron deficiency signaling or iron distribution, indicate that FRD3 is an important component of iron homeostasis in Arabidopsis.

PMID:
12172022
[PubMed - indexed for MEDLINE]
PMCID:
PMC151465
Free PMC Article
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