Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Biol Ther. 2002 Mar-Apr;1(2):189-94.

Quantitative selection constants.

Author information

  • 1Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA. sk@jhmi.edu

Abstract

The study of the genetics of human tumors produces numerical data concerning the frequencies of mutation of individual genes. These frequencies are dependent on a number of processes that act individually and differentially upon genes, and can in turn be conceptualized in quantitative terms to encompass the rates of random mutations within cells, the efficiencies of the evolution of initial mutations to produce the functional inactivation of genes, and selective pressures that act upon cellular populations. Some intuitive mathematical models can be used to organize and formalize our interpretation of the mutation rates of tumor-suppressor genes.

PMID:
12170779
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Landes Bioscience
    Loading ...
    Write to the Help Desk