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BMJ. 2002 Aug 10;325(7359):301.

Accuracy of cervicovaginal fetal fibronectin test in predicting risk of spontaneous preterm birth: systematic review.

Author information

  • 1Academic Department of Obstetrics and Gynaecology, Birmingham Women's Hospital, Birmingham B15 2TG. h.honest@bham.ac.uk

Abstract

OBJECTIVE:

To determine the accuracy with which a cervicovaginal fetal fibronectin test predicts spontaneous preterm birth in women with or without symptoms of preterm labour.

DESIGN:

Systematic quantitative review of studies of test accuracy.

DATA SOURCES:

Medline, Embase, PASCAL, Biosis, Cochrane Library, Medion, National Research Register, SCISEARCH, conference papers, manual searching of bibliographies of known primary and review articles, and contact with experts and manufacturer.

STUDY SELECTION:

Two reviewers independently selected and extracted data on study characteristics, quality, and accuracy.

DATA EXTRACTION:

Accuracy data were used to form 2x2 contingency tables with spontaneous preterm birth before 34 and 37 weeks' gestation and birth within 7-10 days of testing (for symptomatic pregnant women) as reference standards. Data were pooled to produce summary receiver operating characteristic curves and summary likelihood ratios for positive and negative test results.

DATA SYNTHESIS:

64 primary articles were identified, consisting of 28 studies in asymptomatic women and 40 in symptomatic women, with a total of 26 876 women. Among asymptomatic women the best summary likelihood ratio for positive results was 4.01 (95% confidence interval 2.93 to 5.49) for predicting birth before 34 weeks' gestation, with corresponding summary likelihood ratio for negative results of 0.78 (0.72 to 0.84). Among symptomatic women the best summary likelihood ratio for positive results was 5.42 (4.36 to 6.74) for predicting birth within 7-10 days of testing, with corresponding ratio for negative results of 0.25 (0.20 to 0.31).

CONCLUSION:

Cervicovaginal fetal fibronectin test is most accurate in predicting spontaneous preterm birth within 7-10 days of testing among women with symptoms of threatened preterm birth before advanced cervical dilatation.

Comment in

PMID:
12169504
[PubMed - indexed for MEDLINE]
PMCID:
PMC117763
Free PMC Article

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