Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Ethnopharmacol. 2002 Sep;82(1):19-22.

Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats.

Author information

  • 1Division of Biochemistry, Central Drug Research Institute, Lucknow 226001, India.

Abstract

The lipid lowering activity (LLA) of Phyllanthus niruri has been studied in triton and cholesterol fed hyperlipemic rats. Serum lipids were lowered by P. niruri extract orally fed (250 mg/kg b.w.) to the triton WR-1339 induced hyperlipemic rats. Chronic feeding of this drugs (100 mg/kg b.w.) in animals simultaneously fed with cholesterol (25 mg/kg b.w.) for 30 days caused lowering in the lipids and apoprotein levels of VLDL and LDL in experimental animals. The LLA of this drug is mediated through inhibition of hepatic cholesterol biosynthesis, increased faecal bile acids excretion and enhanced plasma lecithin: cholesterol acyltransferase activity.

Copyright 2002 Elsevier Science Ireland Ltd.

PMID:
12169400
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk