Int J Oncol. 2002 Sep;21(3):461-8.

Gene therapy for ovarian cancer (review).

Source

Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 440, Houston, TX 77030, USA. jwolf@mdanderson.org

Abstract

The field of gene therapy presents exciting new opportunities for advances in the management of ovarian cancer. Clinical trials of gene therapy for ovarian cancer have explored the feasibility of delivering a variety of agents as well as highlighted problems with the delivery of therapeutic constructs. Major challenges include enhancing gene transfection with improved vectors, minimizing immunogenicity of viral vectors via novel molecular alterations, effecting tumor-selective gene delivery by targeting genetic alterations present only in tumor cells and utilizing tissue-specific promoters for selective transcription of gene products. Gene therapy research presents unique opportunities for extending the spectrum of ovarian cancer treatment possibilities, either alone or in combination with conventional chemotherapy regimens.

PMID:: 12168087; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Spandidos Publications - PDF

Other Literature Sources

Education

New England Research Institutes Inc.

Medical

Molecular Biology Databases

GANCICLOVIR - HSDB

Supplemental Content

Related citations

The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy. [J Gene Med. 2003]
The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy.
Barker SD, Coolidge CJ, Kanerva A, Hakkarainen T, Yamamoto M, Liu B, Rivera AA, Bhoola SM, Barnes MN, Alvarez RD, et al. J Gene Med. 2003 Apr; 5(4):300-10.
Delivery of herpes simplex thymidine kinase bystander effect by engineered human mesothelial cells for the treatment of ovarian cancer. [Cytotherapy. 2003]
Delivery of herpes simplex thymidine kinase bystander effect by engineered human mesothelial cells for the treatment of ovarian cancer.
Rancourt C, Bergeron C, Lane D, Garon G, Piché A. Cytotherapy. 2003; 5(6):509-22.
[In vitro treatment of ovarian cancer cells with cytosine deaminase-thymidine kinase fusion disuicide gene therapy system under the control of human telomerase reverse transcriptase gene promoter]. [Zhonghua Fu Chan Ke Za Zhi. 2004]
[In vitro treatment of ovarian cancer cells with cytosine deaminase-thymidine kinase fusion disuicide gene therapy system under the control of human telomerase reverse transcriptase gene promoter].
Kong BH, Song Y, Ma DX, Qu X, Jiang S. Zhonghua Fu Chan Ke Za Zhi. 2004 Jun; 39(6):390-5.
Review [Gene therapy for ovarian cancer]. [Nihon Rinsho. 2005]
Review [Gene therapy for ovarian cancer].
Hamada K. Nihon Rinsho. 2005 Dec; 63 Suppl 12:552-61.
Review Gene therapy in human cancer: report of human clinical trials. [Cancer Invest. 2000]
Review Gene therapy in human cancer: report of human clinical trials.
Wasil T, Buchbinder A. Cancer Invest. 2000; 18(8):740-6.

See reviews... See all...

Cited by 4 PubMed Central articles

Preparation and characterization of magnetic nanoparticles containing Fe(3)O(4)-dextran-anti-β-human chorionic gonadotropin, a new generation choriocarcinoma-specific gene vector. [Int J Nanomedicine. 2011]
Preparation and characterization of magnetic nanoparticles containing Fe(3)O(4)-dextran-anti-β-human chorionic gonadotropin, a new generation choriocarcinoma-specific gene vector.
Jingting C, Huining L, Yi Z. Int J Nanomedicine. 2011; 6:285-94. Epub 2011 Feb 2.
DNA as therapeutics; an update. [Indian J Pharm Sci. 2009]
DNA as therapeutics; an update.
Saraswat P, Soni RR, Bhandari A, Nagori BP. Indian J Pharm Sci. 2009 Sep; 71(5):488-98.
Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer. [J Cell Physiol. 2006]
Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer.
Emdad L, Sarkar D, Lebedeva IV, Su ZZ, Gupta P, Mahasreshti PJ, Dent P, Curiel DT, Fisher PB. J Cell Physiol. 2006 Aug; 208(2):298-306.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Gene therapy for ovarian cancer (review).
Gene therapy for ovarian cancer (review).
Int J Oncol. 2002 Sep ;21(3):461-8.

PubMed
Prevalence of tubo-ovarian abscess in adolescents diagnosed with pelvic inflamma...
Prevalence of tubo-ovarian abscess in adolescents diagnosed with pelvic inflammatory disease in a pediatric emergency department.
Pediatr Emerg Care. 2006 Sep ;22(9):621-5.

PubMed
A localizable, biological-based system for the delivery of bioactive IGF-1 utili...
A localizable, biological-based system for the delivery of bioactive IGF-1 utilizing microencapsulated genetically modified human fibroblasts.
ASAIO J. 2009 May-Jun ;55(3):259-65.

PubMed
Treatment expectancy and credibility are associated with the outcome of both phy...
Treatment expectancy and credibility are associated with the outcome of both physical and cognitive-behavioral treatment in chronic low back pain.
Clin J Pain. 2008 May ;24(4):305-15.

PubMed
Yoga in cardiac health (a review).
Yoga in cardiac health (a review).
Eur J Cardiovasc Prev Rehabil. 2004 Oct ;11(5):369-75.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Gene therapy for ovarian cancer (review).

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Education

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information