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J Nutr. 2002 Aug;132(8 Suppl):2406S-2409S.

DNA methylation and atherosclerosis.

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  • 1Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

DNA methylation is a major epigenetic modification of the genome that has the potential to silence gene expression. Recently, the role of epigenetic alteration as a distinct and crucial mechanism to regulate genes governing cell proliferation in atherosclerosis has emerged. Aberrant methylation is related to aging, and, because it affects a large number of CpG islands, age-related methylation may be an important contributor to increased atherosclerosis among older individuals by upregulating atherosclerosis-susceptible genes and downregulating atherosclerosis-protective genes. Further dissection of epigenetic alterations in atherosclerosis and aging will lead to the identification of novel epigenetic modifiers and improved diagnosis and treatment for atherosclerosis-related diseases.

PMID:
12163701
[PubMed - indexed for MEDLINE]
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