Designing supramolecular protein assemblies.

UCLA Department of Chemistry and Biochemistry, 611Charles E Young Drive East, University of California, Los Angeles, 90095-1569, USA. yeates@mbi@ucla.edu

Many natural proteins self-assemble, either to fulfill their biological function or as part of a pathogenic process. Biological assembly phenomena such as amyloidogenesis, domain swapping and symmetric oligomerization are inspiring new strategies for designing proteins that self-assemble to form supramolecular complexes. Recent advances include the design of novel proteins that assemble into filaments, symmetric cages and regular arrays.

PMID: 12163069 [PubMed - indexed for MEDLINE]