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1: Mol Cell Biochem. 2002 May-Jun;234-235(1-2):277-82.Click here to read Links

Arsenic carcinogenicity: relevance of c-Src activation.

Simeonova PP, Luster MI.

Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA. phs9@cdc.gov

Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation.

PMID: 12162444 [PubMed - indexed for MEDLINE]