J Neuroimmunol. 2002 Aug;129(1-2):115-24.

LF 15-0195 prevents from the development and inhibits the progression of rat experimental autoimmune myasthenia gravis.

Duplan V, Dutartre P, Druet P, Saoudi A.

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Institut National de la Santé et de la Recherche Médicale U563, and Université Paul Sabatier, Hôpital Purpan, Toulouse, France.

Abstract

Experimental autoimmune myasthenia gravis (EAMG) is a T cell-dependent antibody-mediated neuromuscular autoimmune disease induced in susceptible rats by a single immunisation with torpedo acetylcholine receptor (AChR). Here, we report that subcutaneous administration of a novel immunosuppressant, LF 15-0195, is effective in inhibiting the induction and the progression of rat EAMG-suggesting that this drug may be used for preventive and curative treatment. The beneficial effect of LF 15-0195 is accompanied by decreased production of pathogenic autoantibodies and inhibition of the differentiation of antigen specific T cells into effector lymphocytes. These finding suggest that LF 15-0195 is a promising therapeutic for this autoimmune disease.

PMID:: 12161027; [PubMed - indexed for MEDLINE]

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