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Neuron. 2002 Jul 18;35(2):255-65.

Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling.

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  • 1MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, SE1 9RT, London, United Kingdom. corinne.houart@kcl.ac.uk

Abstract

Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tlc, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tlc. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.

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PMID:
12160744
[PubMed - indexed for MEDLINE]
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