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Nat Rev Mol Cell Biol. 2002 Aug;3(8):600-14.

Signal transduction and endocytosis: close encounters of many kinds.

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  • 1Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80111, USA.


Binding of hormones, growth factors and other cell modulators to cell-surface receptors triggers a complex array of signal-transduction events. The activation of many receptors also accelerates their endocytosis. Endocytic transport is important in regulating signal transduction and in mediating the formation of specialized signalling complexes. Conversely, signal-transduction events modulate specific components of the endocytic machinery. Recent studies of protein tyrosine kinases and G-protein-coupled receptors have shed new light on the mechanisms and functional consequences of this bidirectional interplay between signalling and membrane-transport networks.

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