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Am Fam Physician. 2002 Jul 15;66(2):273-80.

Proton pump inhibitors: an update.

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  • 1Grant Medical Center, Columbus, Ohio, USA.

Abstract

Since their introduction in the late 1980s, proton pump inhibitors have demonstrated gastric acid suppression superior to that of histamine H2-receptor blockers. Proton pump inhibitors have enabled improved treatment of various acid-peptic disorders, including gastroesophageal reflux disease, peptic ulcer disease, and nonsteroidal antiinflammatory drug-induced gastropathy. Proton pump inhibitors have minimal side effects and few significant drug interactions, and they are generally considered safe for long-term treatment. The proton pump inhibitors omeprazole, lansoprazole, rabeprazole, and the recently approved esomeprazole appear to have similar efficacy.

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PMID:
12152963
[PubMed - indexed for MEDLINE]
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