Postgrad Med J. 2002 Jul;78(921):393-8.

Neurological complications of coeliac disease.

Pengiran Tengah DS, Wills AJ, Holmes GK.

Source

Department of Gastroenterology, Derbyshire Royal Infirmary, London Road, Derby DE1 2QY, UK.

Abstract

A variety of neurological disorders have been reported in association with coeliac disease including epilepsy, ataxia, neuropathy, and myelopathy. The nature of this association is unclear and whether a specific neurological complication occurs in coeliac disease remains unproved. Malabsorption may lead to vitamin and trace element deficiencies. Therefore, patients who develop neurological dysfunction should be carefully screened for these. However, malabsorption does not satisfactorily explain the pathophysiology and clinical course of many of the associated neurological disorders. Other mechanisms proposed include altered autoimmunity, heredity, and gluten toxicity. This review attempts to summarise the literature and suggests directions for future research.

PMID:: 12151653; [PubMed - indexed for MEDLINE]
PMCID:: PMC1742420

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Glutens

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

GLUTEN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Review The neurology and neuropathology of coeliac disease. [Neuropathol Appl Neurobiol. 2000]
Review The neurology and neuropathology of coeliac disease.
Wills AJ. Neuropathol Appl Neurobiol. 2000 Dec; 26(6):493-6.
Review Neurological complications of coeliac disease: what is the evidence? [Pract Neurol. 2008]
Review Neurological complications of coeliac disease: what is the evidence?
Grossman G. Pract Neurol. 2008 Apr; 8(2):77-89.
Review Neurologic presentation of celiac disease. [Gastroenterology. 2005]
Review Neurologic presentation of celiac disease.
Bushara KO. Gastroenterology. 2005 Apr; 128(4 Suppl 1):S92-7.
Review The neurology of gluten sensitivity: separating the wheat from the chaff. [Curr Opin Neurol. 2002]
Review The neurology of gluten sensitivity: separating the wheat from the chaff.
Wills AJ, Unsworth DJ. Curr Opin Neurol. 2002 Oct; 15(5):519-23.
Clinical findings and anti-neuronal antibodies in coeliac disease with neurological disorders. [Scand J Gastroenterol. 2002]
Clinical findings and anti-neuronal antibodies in coeliac disease with neurological disorders.
Volta U, De Giorgio R, Petrolini N, Stangbellini V, Barbara G, Granito A, De Ponti F, Corinaldesi R, Bianchi FB. Scand J Gastroenterol. 2002 Nov; 37(11):1276-81.

See reviews... See all...

Cited by 4 PubMed Central articles

Celiac disease and myointimal proliferation: a possible correlation? [Case Rep Gastroenterol. 2008]
Celiac disease and myointimal proliferation: a possible correlation?
Merra G, Lago AD, Roccarina D, Gasbarrini G, Gasbarrini A, Ghirlanda G. Case Rep Gastroenterol. 2008 Sep; 2(3):398-404. Epub 2008 Nov 14.
An unusual cause of adult onset cerebellar ataxia with hypogonadism. [Ann Indian Acad Neurol. 2009]
An unusual cause of adult onset cerebellar ataxia with hypogonadism.
Menon RN, Sanghani N, Javali M, Jain N, Shah AB. Ann Indian Acad Neurol. 2009 Jan; 12(1):40-4.
Sensorineural hearing loss and celiac disease: a coincidental finding. [Can J Gastroenterol. 2009]
Sensorineural hearing loss and celiac disease: a coincidental finding.
Volta U, Ferri GG, De Giorgio R, Fabbri A, Parisi C, Sciajno L, Castellari A, Fiorini E, Piscaglia M, Barbara G, et al. Can J Gastroenterol. 2009 Aug; 23(8):531-5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Neurological complications of coeliac disease.
Neurological complications of coeliac disease.
Postgrad Med J. 2002 Jul ;78(921):393-8.

PubMed
Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant.
Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant.
N Engl J Med. 2002 Aug 1 ;347(5):330-8.

PubMed
New approaches towards the identification of antibiotic and vaccine targets in S...
New approaches towards the identification of antibiotic and vaccine targets in Streptococcus pneumoniae.
EMBO Rep. 2002 Aug ;3(8):728-34.

PubMed
Cell adhesion molecule expression in the dorsolateral prefrontal cortex and ante...
Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly.
Br J Psychiatry. 2002 Aug ;181:129-34.

PubMed
Do the epilepsies, pain syndromes, and affective disorders share common kindling...
Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms?
Epilepsy Res. 2002 Jun ;50(1-2):203-19.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: