Babesiosis in humans: a treatment review. [Expert Opin Pharmacother. 2002]

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1: Expert Opin Pharmacother. 2002 Aug;3(8):1109-15. Links

Comment in:: Expert Opin Pharmacother. 2002 Nov;3(11):1541-2.

Babesiosis in humans: a treatment review.

Weiss LM.

Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Room 504 Forchheimer Building, Bronx, New York, 10461, USA. lmweiss@aecom.yu.edu

Human infections with Babesia species, in particular Babesia microti, are tick-borne illnesses that are being recognised with increased frequency. Coinfection with ehrlichiosis and Lyme disease is also being recognised as an important feature of these tick-borne illnesses. Despite the superficial resemblance of Babesia to malaria, these piroplasms do not respond to chloroquine or other similar drugs. However, the treatment of babesiosis using a clindamycin-quinine combination has been successful. Data in animal models and case-reports in humans have suggested that an atovaquone-azithromycin combination is also effective. This was confirmed in a recent prospective, open, randomised trial of clindamycin-quinine versus azithromycin-atovaquone. This paper reviews the literature on the treatment of human babesiosis and the animal models of these human pathogens.

PMID: 12150690 [PubMed - indexed for MEDLINE]

Atovaquone and azithromycin for the treatment of babesiosis. [N Engl J Med. 2000]
Atovaquone in the treatment of Babesia microti infections in hamsters. [Am J Trop Med Hyg. 1996]
The treatment of babesiosis. [N Engl J Med. 2001]
Atovaquone and azithromycin treatment for babesiosis in an infant. [Pediatr Infect Dis J. 2007]
Atovaquone plus cholestyramine in patients coinfected with Babesia microti and Borrelia burgdorferi refractory to other treatment. [Adv Ther. 2006]
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Babesiosis in humans: a treatment review.

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