Mutat Res. 1975 Dec;33(2-3):357-66.

DNA strained breakage repair in ataxia telangiectasia fibroblast-like cells.

Vincent RA Jr, Sheridan RB 3rd, Huang PC.

Abstract

Human diploid fibroblast-like cells derived from four patients with the genetic disease ataxia telangiectasia and from two non-mutant donors were examined for the repair of X-ray induced strand breaks in DNA. The ataxia telangiectasia cultures showed no significant differences from the non-mutant cultures in the kinetics and extent of strand repair. This suggests that the increased spontaneous and X-ray induced chromatid aberrations observed in ataxia telangiectasia cells are not caused by a defect in the repair of single strand breaks as might be suspected from a general model of aberration production.

PMID:: 1214827; [PubMed - indexed for MEDLINE]

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The production and repair of double strand breaks in cells from normal humans and from patients with ataxia telangiectasia. [Biochim Biophys Acta. 1977]
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Cited by 2 PubMed Central articles

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