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Dev Neurosci. 2002;24(1):35-46.

Fibroblast growth factors and their receptors in oligodendrocyte development: implications for demyelination and remyelination.

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  • 1Department of Neuroscience, University of Connecticut School of Medicine, Farmington 06030-3401, USA.


Fibroblast growth factors are a family of broad-spectrum growth factors influencing a plethora of cellular activities. The interaction of at least 23 ligands, 4 receptors and multiple coreceptors provides a dramatic complexity to a signaling system capable of effecting a multitude of responses. This review focuses on the fibroblast growth factors signaling in oligodendrocyte development, function and discusses implications for demyelination/remyelination.

Copyright 2002 S. Karger AG, Basel

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