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Trends Genet. 2002 Aug;18(8):405-12.

Yeast go the whole HOG for the hyperosmotic response.

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  • 1Dept of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0448, USA.


An evolutionarily conserved mitogen-activated protein kinase pathway--the high osmolarity glycerol (HOG) pathway--mediates the hyperosmotic response in Saccharomyces cerevisiae. A variety of powerful approaches has generated a comprehensive picture of how cells respond to this stress condition. Several presumptive osmosensors on the cell surface recruit and activate downstream signaling components, which regulate the activity of transcription factors to control gene expression.

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