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Theriogenology. 2002 Jun;57(9):2247-56.

Reproductive toxicity and infertility effect of Ferula hornonis extracts in mice.

Author information

  • 1Department of Biological Sciences, Mu'tah University, Al-Karak, Jordan. merzahh@yahoo.com


The anti-fertility, anti-implantation, and ovarian histological alterations of the ethanolic extract of Ferula hormonis have been investigated in female mice. The intragastric application of 3 mg/kg per day of such extract for 6 weeks resulted in a significant reduction in female mice fertility. Furthermore, it caused a decrease in the number of mated females, the total number of implantations, and the number of viable fetuses. These changes were also associated with ovarian atrophy and a concomitant increase in the connective tissue. The ova showed degeneration while most of the ovarian follicles suffered follicular atresia.

[PubMed - indexed for MEDLINE]
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