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Gene. 2002 Jun 26;293(1-2):199-204.

Metal resistance in yeast mediated by the expression of a maize 20S proteasome alpha subunit.

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  • 1Laboratoire de Biochimie et Physiologie Moléculaire des Plantes, CNRS UMR 5004 Université Montpellier 2, Agro-M/INRA, Montpellier, France.


Transformation of yeast cells with a maize cDNA ZmPAA, encoding a 20S proteasome alpha-subunit, conferred resistance to nickel, cadmium and cobalt. This resistance is not linked to a modification of the intracellular nickel content, as no accumulation of nickel was measured between yeast cells transformed with a void vector or the ZmPAA cDNA. The abundance of the ZmPAA mRNA was increased in the shoots of maize plants upon nickel treatment. These results suggest that the proteasome might be involved in nickel resistance by scavenging metal oxidized proteins both in plants and yeast.

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