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Fertil Steril. 2002 Aug;78(2):404-11.

A randomized controlled trial of laparoscopic ovarian diathermy versus gonadotropin therapy for women with clomiphene citrate-resistant polycystic ovary syndrome.

Author information

  • 1Department of Obstetrics and Gynaecology, University of Auckland, National Women's Hospital, Auckland, New Zealand. c.farquhar@auckland.ac.nz

Abstract

OBJECTIVE:

To compare the effectiveness of laparoscopic ovarian diathermy with gonadotropin ovulation induction for women with clomiphene citrate-resistant polycystic ovary syndrome.

DESIGN:

Randomized controlled trial.

SETTING:

A tertiary referral fertility clinic.

PATIENT(S):

Women with anovulatory infertility secondary to clomiphene-resistant polycystic ovary syndrome. Inclusion criteria were age of <39 years, body mass index of <35 kg/m(2), failure to ovulate with 150 mg of clomiphene citrate for 5 days in the early follicular phase, >12 months of infertility, and no other causes of infertility.

INTERVENTION(S):

Laparoscopic ovarian diathermy versus three cycles of urinary or recombinant gonadotropins.

MAIN OUTCOME MEASURE(S):

Cumulative pregnancy and miscarriage rates.

RESULT(S):

Cumulative pregnancy rates were 28% at 6 months for laparoscopic ovarian diathermy and 33% for three cycles of ovulation induction with gonadotropins. There were three miscarriages in each group. Women in the laparoscopic ovarian diathermy arm of the study had four additional spontaneous pregnancies 6 to 12 months after surgery.

CONCLUSION(S):

There was no statistically significant difference in pregnancy or miscarriage rates during the 6-month follow-up period or the three cycles. Laparoscopic ovarian diathermy is a safe and effective alternative to ovulation induction with gonadotropins.

PMID:
12137881
[PubMed - indexed for MEDLINE]
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