Format

Send to

Choose Destination
See comment in PubMed Commons below
J Am Chem Soc. 2002 Jul 31;124(30):8876-83.

Peptide dendrimers based on polyproline helices.

Author information

  • 1Departament de Química Orgànica, Universitat de Barcelona, Martí i Franquès 1, 08028-Barcelona, Spain.

Abstract

We present a new family of peptide dendrimers based on polyproline helices and cis-4-amino-L-proline as a branching unit. Dendrimers were synthesized by a convergent solid-phase peptide synthesis approach. The conformational transition between polyproline type I helix and polyproline type II helix was observed by circular dichroism in branched polyproline building blocks with more than 14 proline residues and in the resulting dendrimers. Both linear and dendritic polyprolines were found to be actively internalized by rat kidney cells. Preliminary results show that the antibiotic ciprofloxacin form complexes with branched polyproline chains in 99.5% propanol.

PMID:
12137542
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Write to the Help Desk